Xu M, Senanayaka D, Zhao R, Chigumira T, Tripathi A, Tones J, Lackner RM, Wondisford AR, Moneysmith LN, Hirschi A, Craig S, Alishiri S, O'Sullivan RJ, Chenoweth DM, Reiter NJ, Zhang H. TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells. Nat Commun. 2024 Mar 9;15(1):2165. doi: 10.1038/s41467-024-46509-z. PMID: 38461301; PMCID: PMC10925046.
Thosar SA, Barnes RP, Bhargava R, Wondisford AR, O'Sullivan RJ and Opresko PL. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Reports 43(1):113656 (2023).
Groslambert J, Prokhorova E, Wondisford AR, Tromans-Coia C, Giansanti C, Jansen J, Timinszky G, Dobbelstein M, Ahel D, O’Sullivan RJ, Ahel I. The interplay of TARG1 and PARG protects against genomic instability. Cell Reports 6;42(9):113113 (2023).
Rose AM, Goncalves T, Cunniffe S, Geiller HEB, Kent T, Shepherd S, Ratnaweera M, O'Sullivan RJ, Gibbons RJ, Clynes D. Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA. Nucleic Acids Research 51(13):6509-6527 (2023).
Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Molecular Cell 18;83(10):1743-1760.e11 (2023).
Kaminski N, Wondisford AR, Youngho K, Lynskey ML, Bhargava R, Barroso-González J, GarcíaExpósito L, He B,Xu, Mellaharevu D, Watkins SC, Modesti M, Nesvizhskii AI, Zhang H, Sung P and O’Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Molecular Cell 82(21):4001-4017.e7(2022).
Barroso-González J, García-Expósito L, Galaviz P, Lynskey ML, Allen JAM, Hoang S, Watkins SC, Pickett HA, O'Sullivan RJ. Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair. Cell Reports 37(10):110088. doi: 10.1016/j.celrep.2021.110088. (2021)
Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol Cell. 81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. (2021)
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Nature Structure & Molecular Biology 27(12):1152-1164. doi: 10.1038/s41594-020-0512-7 (2020).
Gonzalez JB, Garcia-Exposito L, Hoang SM, Roncaioli JL, Ghosh A, Wallace CW, Modesti M, Bernstein KA, Sarkar SN, Watkins SC and O’Sullivan RJ. RAD51AP1 is a critical mediator of Alternative Lengthening of Telomeres. Molecular Cell. DOI:https://doi.org/10.1016/j.molcel.2019.06.043
Ghosh A, Shao L, Sampath P, Zhao B, Patel NV, Zhu J, Behl B, Parise RA, Beumer JH, O'Sullivan RJ, DeLuca NA, Thorne SH, Rathinam VAK, Li P, Sarkar SN. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Immunity. 50(1):51-63.e5. (2019)
Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A, Bartenhagen C, Walter E, […..], Eggert A, Speleman F, O'Sullivan RJ, Thomas RK, Berthold F, Vandesompele J, Schramm A, Westermann F, Schulte JH, Peifer M, Fischer M. A mechanistic classification of clinical phenotypes in neuroblastoma. Science. 362(6419):1165-1170. (2018)
Roy S, LaFramboise WA, Liu TC, Cao D, Luvison A, Miller C, Lyons MA, O'Sullivan RJ, Zureikat AH, Hogg ME, Tsung A, Lee KK, Bahary N, Brand RE, Chennat JS, Fasanella KE, McGrath K, Nikiforova MN, Papachristou GI, Slivka A, Zeh HJ and Singhi AD. Loss of Chromatin Remodeling Proteins and/or CDKN2A Associates With Metastasis of Pancreatic Neuroendocrine Tumors and Reduced Patient Survival Times. Gastroenterology. S0016-5085(18)30243-9. (2018)
Exposito LG and O'Sullivan RJ. TZAP-ing telomeres down to size. EMBO Rep. 18(6):861-863. (2017)
Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS and O'Sullivan RJ. Proteomic profiling reveals a specific role for translesion DNA Polymerase n in the Alternative Lengthening of Telomeres. Cell Reports. 17(7):1858-1871. (2016)
Singhi AD, Liu TC, Roncaioli JL, Cao D, Zeh HJ, Zureiket AH, Tsung A, Marsh JW, Lee KK, Hogg ME, Bahary N, McGrath K, Nikiforova MN, Slivka A, Cressman KL, Fuhrer K and O’Sullivan, RJ. Alternative Lengthening of Telomeres and loss of DAXX/ATRX expression predicts metastatic disease and poor survival in patients with Pancreatic Neuroendocrine tumors. Clin. Cancer Res. 1113:2016 (2015)
Peifer M, Hertwig F,[…], O’Sullivan, RJ, Westermann F, Thomas RK and Fischer M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 526(7575): 700-704 (2015)
Cesare AJ, Heaphy CM and O’Sullivan, RJ. Methods to visualize telomere structure and dynamics. Current Protoc Cytom. 73:12.40. (2015)
Bulut-Karslioglu A, De La Rosa Velazquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galan C, Winter GE, Engist B, Berle B, O'Sullivan RJ, Martens JHA, Walter J, Manke T, Lachner M and Jenuwein T. Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells. Molecular Cell. 55(2)-277-290. (2014)
O'Sullivan RJ & Almouzni G. Assembly of Telomeric chromatin to create ALTernative endings. Trends in Cell Biology. 24(11):675-685. (2014)
O’Sullivan RJ, Arnoult N, Oganesian, L, Haggblom C, Corpet, A, Almouzni G and Karlseder J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nature Structural and Molecular Biology. 20(2): 167-74. (2014)
O’Sullivan RJ & Karlseder J. The great unravelling; chromatin as a modulator of the aging process. Trends Bio. Sci 37(11):466-76. (2012)
O’Sullivan RJ, Kubicek S, Schreiber S, and Karlseder J. Reduced histone biosynthesis and redistribution of chromatin marks during aging arising from a chronic damage signal at human telomeres. Nature Structural and Molecular Biology. 17(10): 1218-25. (2011)
Corpet A, De Koning L, Toedling J, Savignini A, Boumendil C, Servant N, O’Sullivan RJ, Karlseder J, Barrilot E, Asselain B, Sastre-Garau X and Almouzni G. Regulation of Asf1b reflects proliferating capacity and provides a marker with prognostic value in breast cancers. EMBO. 30(3): 480-93. (2011)
Flynn RL, Centore RC*, O'Sullivan RJ*, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 471(7339): 532-6. (2011)
O’Sullivan RJ & Karlseder J. Telomeres: protecting chromosomes against genome instability. Nat. Rev. Mol. Cell. Biol., 11(3): 171-81. (2010)